منابع مشابه
The signaling mechanisms underlying cell polarity and chemotaxis.
Chemotaxis--the directed movement of cells in a gradient of chemoattractant--is essential for neutrophils to crawl to sites of inflammation and infection and for Dictyostelium discoideum (D. discoideum) to aggregate during morphogenesis. Chemoattractant-induced activation of spatially localized cellular signals causes cells to polarize and move toward the highest concentration of the chemoattra...
متن کاملSignaling Pathways Controlling Microglia Chemotaxis
Microglia are the primary resident immune cells of the central nervous system (CNS). They are the first line of defense of the brain's innate immune response against infection, injury, and diseases. Microglia respond to extracellular signals and engulf unwanted neuronal debris by phagocytosis, thereby maintaining normal cellular homeostasis in the CNS. Pathological stimuli such as neuronal inju...
متن کاملThermal Robustness of Signaling in Bacterial Chemotaxis
Temperature is a global factor that affects the performance of all intracellular networks. Robustness against temperature variations is thus expected to be an essential network property, particularly in organisms without inherent temperature control. Here, we combine experimental analyses with computational modeling to investigate thermal robustness of signaling in chemotaxis of Escherichia col...
متن کاملReconstitution of signaling in bacterial chemotaxis.
Strains missing several genes required for chemotaxis toward amino acids, peptides, and certain sugars were tethered and their rotational behavior was analyzed. Null strains (called gutted) were deleted for genes that code for the transducers Tsr, Tar, Tap, and Trg and for the cytoplasmic proteins CheA, CheW, CheR, CheB, CheY, and CheZ. Motor switch components were wild type, flaAII(cheC), or f...
متن کاملNavigating signaling networks: chemotaxis in Dictyostelium discoideum.
Studies of chemotaxis in the social amoeba Dictyostelium discoideum have revealed numerous conserved signaling networks that are activated by chemoattractants. In the presence of a uniformly distributed stimulus, these pathways are transiently activated, but in a gradient they are activated persistently and can be localized to either the front or the back of the cell. Recent studies have begun ...
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ژورنال
عنوان ژورنال: Development, Growth & Differentiation
سال: 2011
ISSN: 0012-1592
DOI: 10.1111/j.1440-169x.2011.01265.x